Paul Krumpöck

Home: Vienna Medical University
Host: Stanford University School of Medicine
Topic: Genetic underpinnings of acquired hearing loss

During my stay as a visiting scholar at Stanford University School of Medicine, I am conducting research as part of the Stanford Initiative to Cure Hearing Loss. More specifically, my project tackles the complex genetic underpinnings of acquired hearing loss, a major global health issue whose genetic causes are still not well understood.

In collaboration with other research groups at Stanford and Google, we use biomedically trained large language models to analyze vast genomic datasets, aiming to identify novel genes responsible for hearing loss. The most promising genetic candidates identified by the AI will then be validated in the "wet lab." Using CRISPR-Cas9 genome editing, we will create mouse models to study the effects of these genes. We will then assess their hearing function using methods like auditory brainstem response (ABR) measurements and examine the cellular structures of the inner ear through advanced microscopy.

This interdisciplinary approach combines the power of computational genomics with rigorous biological validation. The ultimate aim is to uncover new therapeutic targets and pave the way for gene-based therapies and personalized treatments for people with hearing loss. I am incredibly grateful to the Marshall Plan Foundation for providing me with the opportunity to contribute to this cutting-edge research at the intersection of medicine and technology.

Paul Krumpöck